Ayodeji A. Olabiyi, Ph.D.

Research Instructor

  • B.Sc. In Biochemistry (2006); University of Ado Ekiti, Nigeria
  • M.Sc. in Applied Biochemistry (2012); Federal University of Technology, Akure. Nigeria
  • Ph.D. in Applied Biochemistry (2018); Federal University of Technology, Akure. Nigeria
  • Faculty (2013 – 2022); Afe Babalola University, Ado Ekiti. Nigeria
  • Postdoc (2021-2022); Universidade Federal de Santa Maria, Camobi. Brazil
  • Postdoc (2022-2026); East Carolina University, USA
  • Research Instructor (2026 – present); East Carolina University, USA

Phone: 252-744-2771
E-mail: olabiyia22@ecu.edu

Research Interest

Over a decade, I have worked extensively on the influence of diet on key biochemical pathways associated with the pathogenesis of some degenerative diseases such as type-2 diabetes and hypertension as well as erectile dysfunction in relation to cardiovascular disease.

Currently, my research interest focuses on the interplay between cardiovascular and renal diseases, with particular emphasis on the molecular and nutritional mechanisms underlying cardiorenal syndrome. I am especially interested in how bioactive nutrients and trace elements influence inflammation, oxidative stress, immune responses, and tissue remodeling following myocardial injury and chronic kidney dysfunction. My work integrates translational approaches including animal models, flow cytometry, proteomics, and molecular biology to identify therapeutic targets that can improve cardiovascular and renal health outcomes.

Publications

  1. Ayodeji A. Olabiyi, de Castro Brás LE (2025). Cardiovascular Ischemia: Advancement and Potential Use of Collagen-Based Therapeutic Strategy. International Journal of Molecular Sciences, 26(19), 9275.
  2. Ayodeji A. Olabiyi, de Castro Brás LE (2023). Cardiovascular Remodeling Post- Ischemia: Herbs, Diet, and Drug Interventions. Biomedicines, 13;11(6)
  3. Adeola O. Adedara, Titilayomi A. Otenaike, Ayodeji A. Olabiyi, Isaac A. Adedara, Amos O. Abolaji. (2023). Neurotoxic and behavioral deficit in Drosophila melanogaster co-exposed to rotenone and iron. Metabolic Brain Disease, 1-12
  4. Victor O. Ukwenya, Adelakun S Aderemi, Olutayo M. Alese, Ayodeji A Olabiyi. (2022). Caffeic acid abrogates amyloidosis, hypospermatogenesis and cell membrane alterations in the testes and epididymis of fructose-diabetic rats by upregulating steroidogenesis, PCNA and Nrf2 expression. Tissue and Cell, 79, 101912.
  5. Isaac A. Adedara, Thiele P. Souza, Julia Canzian, Ayodeji A. Olabiyi, João V. Borba, Eduarda Biasuz, Giovana R. Sabadin, Falco L. Gonçalves, Fabiano V. Costa, Maria R.C. Schetinger, Ebenezer O. Farombi, Denis B. Rosemberg. (2022). Induction of aggression and anxiety-like responses by perfluorooctanoic acid is accompanied by modulation of cholinergic- and purinergic signaling-related parameters in adult zebrafish. Ecotoxicology and Environmental Safety, 239, 113635.
  6. Ayodeji A. Olabiyi and Kayode Ajayi (2022). Diet, herbs and erectile function: A good friendship! Andrology, e14424.
  7. Ayodeji A. Olabiyi, Olamide S. Tope-Eniola, Adedotun O. Oluwatuyi, Oluwafunmilayo Alabi, Olaoluwa G. Ademola, Opeyemi M. Oguntimehin, Yemisi R. AlliSmith. (2022). Quercetin boosts nitric oxide levels and modulates the activities of arginase, acetylcholinesterase and adenosine deaminase in the corpus cavernosum of cyclosporine-treated rats. Andrology,
  8. Ayodeji A. Olabiyi, Daniela F. Passos, Jean Lucas G. da Silva, Maria R. C. Schetinger, Daniela B. Rosa Leal. (2021). Role of purinergic system and vitamin D in the anti- cancer immune response. Life Sciences, 287, 120110
  9. Ayodeji A.Olabiyi, Yemisi R. AlliSmith, Victor O. Ukwenya (2021). Quercetin enhances sexual behavior and improves ectonucleotidases activity in the hypothalamus of rats treated with cyclosporine. Journal of Food Biochemistry, e13864.
  10. Ayodeji A. Olabiyi, Vera M. Morsch, Ganiyu Oboh and Maria R. C. Schetinger. (2021). Cyperus esculentus L. and Tetracarpidium conophorum Müll. Arg. Supplemented Diet Improved Testosterone Levels, Modulated Ectonucleotidases and Adenosine Deaminase Activities in Platelets from L-NAME Stressed Rats. Nutrients 13, 3529.
  11. Ayodeji A. Olabiyi, Blessing A. Afolabi, Karine P. Reichert,Tais V. Palma, Vera M. Morsch, Ganiyu Oboh, Maria R. C. Schetinger (2021). Assessment of sexual behavior and neuromodulation ofCyperus esculentus and Tetracarpidium conophorum Müll. Arg dietary supplementation regulating the purinergic system in the cerebral cortex of L-NAME-challenged rats. Journal of Food Biochemistry, e13862.
  12. Seun F. Akomolafe and Ayodeji A. Olabiyi (2021). Evaluation of Dietary Supplementation of Pumpkin (Cucurbita pepo L) Seed on Antioxidant Status, Hormonal Level and Sexual Behavior in Male Rats. Tropical Journal of Natural Product Research, 5(5):952-958
  13. Edem E. Edem, Blessing U. Nathaniel, Kate E. Nebo, Abiola O. Obisesan, Ayodeji A.  Olabiyi, Elizabeth T. Akinluyi and Azeez O. Ishola (2021). Lactobacillus plantarum mitigates sexual-reproductive deficits by modulating insulin receptor expression in the hypothalamic-pituitary-testicular axis of hyperinsulinemic mice. Drug Metabolism and Personalized Therapy. 36 (4), 321-336
  14. Ayodeji A. Olabiyi. (2020). In vitro inhibitory effects of Cyperus esculentus (tiger nut) tubers on some enzymes associated with neurodegeneration and Fe2+– peroxidation in rats’ brain tissue homogenate. Nigeria Journal of Neuroscience, 11(2):81-87.
  15. Ayodeji A. Olabiyi, Ganiyu Oboh, Azeez O. Ishola, Philip A. Adeniyi, Aline A. Boligon (2019). Tetracarpidium conophorum Müll. Arg. modulate sexual behaviour and biochemical parameters relevant to erection in Wistar rats. Pathophysiology, 27(4): 251-258.
  16. Naiara Stefanello, Roselia Spanevello, Sabina Passamonti, Lisiane Porciúncula, Carla D. Bonan, Ayodeji A. Olabiyi, João B. Teixeira da Rocha, Charles E. Assmann, Vera M.Morsch, Maria R. C. Schetinger (2019). Coffee, caffeine, chlorogenic acid, and the purinergic system. Food and Chemical Toxicology, 123: 298-313.
  17. Azeezaah F. Ibraheem, Imoleayo A. Ogeleyinbo, Kenny O. Emmanuel, E V. Idar, Joseph O. Oyewale, Oladunni E. Kunlere, Ayodeji A. Olabiyi, Philip A. Adeniyi (2019). Assessment of the Impacts of Selenocysteine on the Dopaminergic System in the Substantia Nigra and Striatum of 6-OHDA Parkinson’s Disease Rat Model. IBRO Reports 7, 25.
  18. Stephen A. Adefegha, Ganiyu Oboh and Ayodeji A. Olabiyi (2018). Nutritional, antioxidant and inhibitory properties of cocoa powder enriched wheat-plantain biscuit on key enzymes linked to type 2 diabetes. International Food Research Journal, 25(2): 793-803.
  19. Ayodeji A. Olabiyi, Fabiano B. Carvalho, Nathieli B. Bottari, Thauan F. Lopes, Pauline da Costa, Naiara Stefanelo, Vera M. Morsch, Ganiyu Oboh, Maria R. C. Schetinger (2018). Dietary supplementation of tiger nut alters biochemical parameters relevant to erectile function after administration of L-NAME in rats. Food Research International, 109: 358-367.
  20. Ayodeji A. Olabiyi, Fabiano B. Carvalho, Nathieli B. Bottari, Vera M. Morsch, Ademir F. Morel, Ganiyu Oboh, Maria R. C. Schetinger (2018): Tiger nut and walnut extracts modulate extracellular metabolism of ATP and adenosine through the NOS / cGMP / PKG signaling pathway in kidney slices, Phytomedicine, 43: 140-149.
  21. Stephen A. Adefegha, Daniela B. Rosa Leal, Ayodeji A. Olabiyi, Ganiyu Oboh & Livia G. Castilhos (2017): Hesperidin attenuates inflammation and oxidative damage in pleural exudates and liver of rat model of pleurisy, Redox Report, 1-9.
  22. Oloruntola J. Bamidele, Philip A..Adeniyi, Ishola A.Olakunle, Ogedengbe O.Oluwatosin, Olatunji B.Peter, Ayodeji A. Olabiyi Shallie P.Dauda. (2017). Behavioural, Biochemical and Neurocytoarchitechural impact of MDMA in male adolescent mice. Anatomy Journal of Africa. 6 (1): 884 -895.
  23. Ayodeji A. Olabiyi, Ganiyu Oboh, Ayodele J. Akinyemi, Adedayo O. Ademiluyi, Aline A. Boligon and Marli M. Anraku de Campos (2017). Tiger nut (Cyperus esculentus L.) supplemented diet modulate key biochemical indices relevant to erectile function in male rats. Journal of Functional Foods 34: 152–158.
  24. Jamiu A. Saliu and Ayodeji A. Olabiyi. (2017). Aqueous extract of Securidaca longipendunculata Oliv. and Olax subscropioidea inhibits key enzymes (acetylcholinesterase and butyrylcholinesterase) linked with Alzheimer’s disease in vitro, Pharmaceutical Biology, 55(1) 252-257.
  25. Ayodeji A. Olabiyi, Ganiyu Oboh and Stephen A. Adefegha. (2017). Effect of dietary supplementation of tiger nut (Cyperus esculentus L.) and walnut (Tetracarpidium conophorum Müll. Arg.) on Sexual behavior, Hormonal level and Antioxidant status in normal male rats. Journal of Food Biochemistry 41 (3)
  26. Roberto M Maciel, Fabiano B Carvalho, Ayodeji A Olabiyi, Roberta Schmatz, Jessié M Gutierres, Naiara Stefanello, Daniela Zanini, Michelle M Rosa, Cinthia M Andradea, Maribel A Rubin, Maria Rosa Schetinger, Vera Maria Morsch, Cristiane C Danesi, Sonia T A Lopes (2016). Neuroprotective effects of quercetin on memory and anxiogenic-like behavior in diabetic rats: Role of ectonucleotidases and acetylcholinesterase activities. Biomedicine and Pharmacotherapy 84: 559-568.
  27. Ayodeji A. Olabiyi, Yemisi R. Alli Smith, Leye J. Babatola, Ayodele J Akinyemi, Ganiyu Oboh. (2016). Inhibitory effect of aqueous extract of different parts of Gossypium herbaceum on key enzymes linked with type 2 diabetes and oxidative stress in rat pancreas in vitro. Beni-Suef University Journal of Basic and Applied Sciences 5:180–186.
  28. Philip A. Adeniyi, Azeez O. Ishola, Ayodeji A. Olabiyi, Babawale P. Olatunji, Akele Y. Richard, Joseph O. Sanya. (2016). The risk of Amphitamine-related stimulants to users and the general population in Nigeria. Nigeria Journal of Neuroscience 7(2): 41- 47.
  29. Jamiu A. Saliu, Ayodeji A. Olabiyi, Stephen A. Adefegha, Sunday Oyeleye, Oluwaseun O. Olorunisola. (2016). Comparative evaluation of Antioxidative properties and effects of aqueous extracts of Cola nitida and Vitex doniana on Fe2+ – generated oxidative stress in rat testes in vitro. The International journal of Biotechnology 5(2): 15-25.
  30. Ayodele J. Akinyemi, Ayodeji A. Olabiyi, Oluwafemi T. Ogunmodede, Sunday A. Onikanni and Scholarstical Anadozie (2015). Inhibitory effect of tannic acid and its derivative (gallic acid) against cisplatin–induced thiobarbituric acid reactive substances (TBARS) production in rat kidney – in vitro. International Journal of Advanced. Research. 3 (1): 116-126.
  31. Ganiyu Oboh, Ayodeji A. Olabiyi, Ayodele J. Akinyemi and Adedayo O. Ademiluyi (2014). Inhibition of key enzymes linked to type 2 diabetes and Sodium nitroprusside – induced lipid peroxidation in rat pancreas by water – extractable phytochemicals from unripe pawpaw fruit (Carica papaya) Journal of Basic and Clinical Physiology and Pharmacology. 25(1): 21 – 34.
  32. Oboh, Ayodeji A. Olabiyi, and Ayodele J. Akinyemi (2013). Inhibitory effect of aqueous extract of different parts of unripe pawpaw (Carica papaya) fruit on Fe2+ – induced oxidative stress in rat pancreas in vitro. Journal of Pharmaceutical Biology. 51 (9): 1165-1174.