Alexandra (Bobbie) Garvin, Ph.D.

Alexandra Garvin

Assistant Professor

Phone: 252-744-0334

Research Interests

The overarching theme of my research program is to examine cell specific – cardiac myocyte and cardiac fibroblast – responses to stress using both cellular and molecular approaches. In the same localized environment, cardiac myocytes become dysfunctional while cardiac fibroblasts proliferate and activate leading to a coordinated induction of heart failure. More than 6 million Americans suffer from heart failure triggered by both acute and chronic disease states. Fibrosis, a primary characteristic of heart failure, is the deposition of extracellular matrix by cardiac fibroblasts that contributes to cardiac stiffening and a decline in cardiac function when produced in excess. My current research direction focuses on cardiac fibroblast phenotype and the molecular mechanisms that govern fibroblast activation and persistence during adverse cardiac remodeling. We utilize animal models of cardiac injury and isolated primary cardiac fibroblasts to identify genetic, proteomic, and metabolic factors that drive and support cardiac fibroblast activation. We are particularly interested in mitochondrial-related mechanisms that support the persistent activation of cardiac fibroblasts. The ultimate goal is to elucidate novel targets for anti-fibrotic therapies to intervene with the progression to heart failure.


  • 2023-present: Assistant Professor
    Department of Physiology, Brody School of Medicine
    East Carolina University
  • 2017-2022: Postdoctoral Fellow
    Department of Basic Medical Sciences
    University of Arizona College of Medicine-Phoenix (mentor: Taben Hale)
  • 2010-2017: Ph.D. degree and postdoctoral scholar
    HUCK Institute for the Life Sciences: Physiology
    The Pennsylvania State University (mentor: Donna Korzick)
  • 2009: B.S. degree in Biology
    Clemson University


Full List of Pubmed Citations